Category: Physiology

  • Dopamine

    Neuroscience as a melody and the body as the orchestra

    Over time study of the brain has progressed with developments in technology to study brain function giving us a science of the brain, Neuroscience. Developments within the field of Neuroscience has provided tantalising insights into the physical and chemical functions of the brain. Associated with these insights, treatments that can assist some people with chronic conditions or offer some relief from difficult psychological states have developed.

    Within this field several core neurochemical pathways have been identified in being instrumental to certain motivational states. To offer a vastly oversimplified model, four neurochemicals Dopamine, Oxytocin, Serotonin and Endorphins relate to Reward, Love, Mood and Pain Relief respectively. In this article, I will explore Dopamine and its relationship with Reward.

    The Carrot

    With his work Awakenings, Oliver Sacks, an eminent Neuroscientist, recorded several case studies in which a chemical substitute for dopamine, L-Dopa was administered to a number of patients with Parkinsons, an extremely degenerative disorder of brain function. The observations from these treatments offer a diverse and intriguing record of how neurochemical pathways in brain function are involved in behaviour, motivation and conscious experience.

    Although the observations of the impact of L-Dopa were varied, for the purpose of this essay it was observed that changes in neurochemicals created behavioural changes that could ‘Awaken’ a patient from catatonia, a sleep like state of zombification. In Awakenings, Sacks states

    ‘..the awakened patient turns to the world, no longer occupied and preoccupied by his sickness. He turns an eager and ardent attention on the world, a loving and joyous and innocent attention, the more so because he has been so long cut-off, or ‘asleep’.’

    For those of us who are fortunate enough to not have to deal with Parkinsonian symptoms these observations can point toward the value of understanding how our brains function. The awakening caused by a change in dopamine like neurochemicals, is one of greater engagement with the world. There is a sense of moving from dysfunction to health with an accompanying movement, from self-involvement toward outward facing attention to life. Such observations can assist us in trying to lead more fulfilling lives, and suggest strategies related to Dopamine function that may improve our own motivation to act and engage with the world.

    Facing outward by discipline inward

    Some years ago, I elected to run a half-marathon and after a number of months of training, I was in relatively good shape to complete the race. However, as yet I had never run such a distance. The day started threateningly as the weather had turned to provide an unseasonably cold October morning. I found myself beset by feelings of resistance as I considered braving the cold and having to wait in line before the race began. In my mind I conceived two outcomes, one in which I refused the challenge and remained home. I considered the disappointment and shame I may feel in light of the temporary relief from the pain of the cold. In opposition to this negative vision, I considered passing the finish line and returning home with the feeling of pride and satisfaction of the achievement. In the light of such contemplation there was no contest, and I left the comfort of home to undertake the race.

    This points me to the first aspect of the psychological reward system, the apprehension of a goal fulfilled. Without the conception of a goal, we are liable to be in a state of reactivity to our circumstances that is likely to induce us to seek homeostasis and security. We turn inward to ourselves and seek to minimise our engagement with the world that can soon appear hostile, threatening our security and comfort. Yet with a compelling goal the world is the arena in which our goal can be realised. A place of challenges, yes but also opportunity. Reward and adventure. The goal shifts our focus from obstruction to opportunity, from captivity to captivating.

    ‘A journey of a 1000 miles begins with a single step.’

    The adage above is a much-sited quotation that offers an insight into a second important aspect of achieving, focus upon the individual actions within themselves. In Awakenings, Oliver Sacks describes the patients prior to their treatments often locked in a catatonia unable to take a single step. This extreme condition is a reflection of a sickened motivational response, in which any action is prevented even in its initiation. Yet all achievements big or small require small consistent and appropriate actions.

    To this end our brains contain a valuable reward system that allows a greater achievement to be experienced, as an evolving journey with consistent rewards. Within my Half-marathon I experienced a relatively direct sense of a consistent reward process, that mirrors how such rewards function. Throughout the race I naturally felt my energy levels fluctuate and as the latter stages approached, I felt an ever-greater sense of exhaustion and fatigue. Yet as I passed each mile marker, I gained a sense of completion with a brief burst of pleasure that allowed me to stay motivated and encouraged. Toward the end of the race, smiling angels in the guise of stewards, offered water and sweets to assist me in the task. Although the glucose was instrumental in the value of these rewards, I also suspect that a degree of dopamine was at work, as I felt encouraged by the support provided both physically and psychologically.

    In essence, I am alluding to the rewards associated with the individual steps taken toward achieving my goal. Highlighting how milestones, pit-stops and my recognition of progress along the way supported me in remaining motivated, engaged and consistent throughout the process. Underlying these experiences are feelings, positive rewards that provide a conscious experience of eager engagement with my chosen task.

    Life as an adventure

    To conclude, I have attempted to utilise the example of my completion of a half-marathon to present some processes that assist psychologically with the fulfilment of a goal. I have postulated that there are dopamine neuropathways as a core mechanism that underlies the brain activity associated with the motivation in achieving such goals. I will provide a caveat that my representation is a vast oversimplification of the processes at work, yet the framework allows an introduction to considering brain function in motivation.

    The ability to clearly apprehend a goal allows us to envision a pathway of fulfilment. Adhering to this pathway can motivate us to undertake the individual tasks that are required to progress on the path. While, feeling consistent rewards as part of that progress allows us to enjoy the process. As such we can consider that it’s not only the final achievements that give our lives meaning, but also the unfolding experiences, successes and failures, that make up the process of fulfilment.

    With this in mind I urge you to consider investing in the power of your brain for motivation. It may serve you to invest the time to create an emotionally compelling vision for your future, and then conceive of the individual tasks that can make that vision a reality. Then act and enjoy the sweet rewards along the way, and the success at the finish line.


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  • The Body

    Person-centred therapy has a central focus upon the concept of ‘conditions of worth’. Conditions of worth are conditions that a person experiences as being necessary to feeling a sense of being of value. Regarding worth, in the past maturity has been seen as a period of veneration and power, yet in modern societies youth tends to be promoted as having greater value. Media often bathes in sexually charged images of youthful bodies. Sex sells. Yet to what extent will an ever-aging population feel a lack of worth in comparison to the youthful images around them?

    The aging process appears to have gotten a hold of me in recent times and I find that my appearance is now firmly in maturity. Upon my attention being drawn to this gradual process I must admit to being beset by a degree of anxiety. I felt this as an unexpected occurrence, as I have mostly appreciated my appearance over the years. I became conscious of the potential of conceiving of myself as ugly and old.

    I have been beset by these thoughts surprisingly suddenly and as I adapt to the associated feelings, I have made a conscious decision to recover a sense of appreciation for my body. In this article I will explore a few key aspects of the body and importantly body awareness, that for me, is a fundamental component to positive mental health.

    Breath

    Breath is the most immediate biological function that also has an interesting feature in that it is both a conscious and unconscious activity. Bringing focus to the breath and controlling how we breathe has been a yogic practice from time immemorial and remains one of the most important practices for relaxation.

    There are a number of breathing practices that are available, yet the simplest is to just be aware of a process that mostly goes unnoticed. The act of placing our attention upon our breath will often cause the breathing to slow and begin to induce relaxation into the body. This can reduce chronic stress and when practiced regularly throughout the day, can aid mental focus.

    Skin

    Our skin is our largest organ and the physical barrier between our bodies and the world. It has the mixed blessing of being both the source of some of our most intense pleasures, yet also excruciating pains. However, in between those extremes are a range of sensations that we may seldom neglect to experience. Touching the objects around us with our attention upon the sensations can be surprisingly rewarding, inviting us into the world of rough and smooth, cold, warm, moist and damp.

    Also, our skin is our point of contact with our fellow human beings and loved ones. Not just in sexuality is intimate touch a blessing, but also the warmth of platonic hugs and caress. It is of note that one of the most distressing aspects of loneliness can be loss of human touch. While also, losing openness to touch can be a tragic symptom of abuse and neglect. Receiving touch is proven to be one of the most essential experiences in reducing stress and is known to relieve shock following a traumatic experience.

    Sight

    Our skin is often the aspect of ourselves that appears to suffer most from the signs of aging. Wrinkles form around the eyes, the forehead shows lines like a road map of our most used expressions. Yet it is with our own eyes that we observe ourselves. Our faces appear to us like the most essential part of who we are, yet they change slowly but surely as we journey through time. Our bodies too are liable to suffer the judgemental gaze, failing to meet some expectation we have created for ourselves. However, we can choose to see our changing image with rejection and distain, or we can love what we see before us if we care to look with compassion and appreciation.

    The Body as a Temple

    In my opinion the most intimate physical relationship we will have is with our body. I hesitate to suggest that we are souls housed within our bodies, yet that is certainly a way our lived experience can be expressed. As such the home that is our body would be best served as a comfortable and functional one. Although we cannot depend upon having such a home throughout the course of our whole lives, I believe we serve ourselves well in aiming to value and preserve what we have while we have it.

    Our bodies are also a major source of our identity and often form part of our conditions of worth. In that sense we would be served well in accepting our changing appearance as a marker of years of life, valuing each season as it dawns upon us.

    Yet there is also an almost hidden secret in the appreciation of the body, in that it is a direct point of access to positive mental health too. Practices of caring for our bodies that involve conscious awareness of our inner sensations offer powerful ways of being in the present moment. This aids us mentally as much of the suffering that ails many of us is produced by thoughts in our imagination. Yogic practices affirm that focus on the body can prove an ever-accessible pathway to relief from mental strife. These practices can help relieve us of the conditions of worth we have for our bodies, allowing us to appreciate our bodies as sacred temples for the soul.


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